Blastic phase of Ph1-positive chronic myeloid leukemia and t(3;21)
نویسندگان
چکیده
4. Kikutani H, Inui S, Sato R, Barsumian E, Owaki H, Yamasaki Y, Kaisho T, Uchibayashi N, Hardy R, Hirano T, Tsunasawa 5, Sakiyama F, Svemura M, Kishimoto T: Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell 47:657, 1986 5. Ikuta K, Takami M, Kim CW, Honjo T, Miyoshi T, Tagaya Y, Kawabe T, Yodoi J: Human Lymphocyte Fc receptor for IgE: Sequence homology of its cloned cDNA with animal lectins. Proc NatI Acad Sci USA 84:819, 1987
منابع مشابه
Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia.
An identical reciprocal translocation between the long arms of chromosomes 3 and 21 with breakpoints in bands 3q26 and 21q22, t(3;21)(q26;q22), was found in three male patients with the blast phase of chronic myelogenous leukemia (CML). The abnormality was clonal in all three patients and was always accompanied by either a standard or variant 9;22 translocation resulting in a Philadelphia chrom...
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A 58-yr-old male patient presented in the blastic phase of chronic myelogenous leukemia (CML). Cytogenetic studies revealed a 45 XO Ph1 chromosome pattern in bone marrow cells during a short remission and again in the blastic phase of the disease. The patient expired 8 mo following diagnosis. The blastic phase of CML can stimulate acute myelogenous leukemia (AML) clinically and hematologically;...
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The sister chromatid exchange (SCE) frequency was studied in the leukemic cells of 12 patients, 10 with Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML), 1 with Ph1-negative CML, and 1 with acute myeloblastic leukemia. Except for two patients in the blastic phase of CML, the SCE values were within the normal range [3.8 +/- 6.4 (S.D.) SCE/cell; normal is 3.3 +/- 2.2 SCE/c...
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We have analyzed the distribution and prognostic significance of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) in connection with conventional cytology, cytogenetics, response to therapy, and survival. The study population consisted of 78 patients with AML, 44 patients with Ph1 + CML in chronic phase, and 35 adult patients with Ph1 + CML in blastic phase, among which...
متن کاملTherapeutic and Prognostic Value of Initial Chromosomal Findings at the Blastic Phase of Ph’-Positive Chronic Myeloid Leukemia
To assess parameters of therapeutic response and of survival after the onset of the blastic phase (BP) in 64 patients with Ph1-positive chronic myeloid leukemia (CML). a number of clinical, hematologic, and cytogenetic data at the BP were evaluated. Among 10 parameters checked, only the chromosomal findings correlated with the therapeutic response and survival after the onset of the BP. The pat...
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ورودعنوان ژورنال:
- Blood
دوره 72 1 شماره
صفحات -
تاریخ انتشار 1988